A multimeter is not really mandatory for the job, you can just rotate the screw with a screwdriver and go by trial and error.
Some say that you need to rotate the screw to the right, others say to the left, others that you can't rotate the screw either way too much or you will burn the laser, etc, but what others say isn't always true.
I've calibrated the lasers on my Dreamcasts a few times - different GD-ROM drive versions; and they all appear to have a mechanism on the screw that makes it possible to be rotated 360ยบ without any problem, that it'll just return to the initial position - if you rotate it too far from the "read zone", the laser will enter a "dead zone" where the disc will spin too slow or too fast and the laser won't be able to read it, even though he tries.
The usual conception is that tweaking the potentiometer will rise/reduce the voltage output to the laser head, making it able to read past scratches, dust, etc, but there's also the idea that is supported by some tech savvy people, that tweaking the potentiometer adjusts the voltage output to the DC motor that spins the discs, and not to the laser head itself.
While I can't be certain about this, because I never dealt with a multimeter onto the GD-ROM disc mechanism PCB, from my experience this is what actually happens, as only the disc spin mechanism suffers behaviour changes and not the laser head, which continues to work as usually does.
Imagine a clock, from my experience, the "read zone" is comprehended between 10 and a half and 1 and a half or so - rotating the screw and placing its pointer (usually a red dot or a bigger indentation) pointed to a direction other than that area, will just make the disc too slow or too fast as I've told.
You can go by trial and error as most people do (rotate screw, place disc, hold the lid lever and see if the game launches, if not, redo the process until it does - its just a question of fine movements sometimes), but if you really want to use a multimeter to be sure, I don't know which voltage/resistance values you must be looking out for, as I don't even know what voltage input the GD-ROM drive takes from the Motherboard/PSU pins.
As for the process itself, there are numerous videos on Youtube, just search for "Dreamcast laser calibration" or something like that
